Ventriculolumbar Perfusion Chemotherapy With Methotrexate for Treating Leptomeningeal Carcinomatosis: A Phase II Study
نویسندگان
چکیده
منابع مشابه
Phase II study of concurrent methotrexate and bleomycin chemotherapy.
Methotrexate and bleomycin are both active in epidermoid tumors. They have different mechanisms of action and different host effects particularly with regard to myelosuppression. The concurrent administration of methotrexate and bleomycin was used in 30 patients with metastatic tumors, primarily epidermoid in type. Ten of 19 patients évaluablefor therapeutic response demonstrated objective tum...
متن کاملComparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone.
OBJECTIVE To compare the efficacy of intrathecal methotrexate single therapy with three-drug combination therapy in patients with leptomeningeal carcinomatosis. METHODS Fifty-five patients who had pathologically proven leptomeningeal carcinomatosis of a solid tumor were evaluated in terms of pathological response. Group M (n = 29) received methotrexate 15 mg and group MHA (n = 26) received me...
متن کاملRecent Advancements of Treatment for Leptomeningeal Carcinomatosis
Treatment of Leptomeningeal carcinomatosis (LMC) from solid cancers has not advanced noticeably since the introduction of intra-cerebrospinal fluid (CSF) chemotherapy in the 1970's. The marginal survival benefit and difficulty of intrathecal chemotherapy injection has hindered its wide spread use. Even after the introduction of intraventricular chemotherapy with Ommaya reservoir, frequent devel...
متن کاملTreatment of Leptomeningeal Carcinomatosis in a Patient With Metastatic Cholangiocarcinoma
A 49-year-old woman with cholangiocarcinoma metastatic to the lungs presented with new-onset unrelenting headaches. A lumbar puncture revealed malignant cells consistent with leptomeningeal metastasis from her cholangiocarcinoma. Magnetic resonance imaging (MRI) of the brain revealed leptomeningeal enhancement. An intrathecal (IT) catheter was placed and IT chemotherapy was initiated with metho...
متن کاملNeuroborreliosis Mimicking Leptomeningeal Carcinomatosis in a Patient With Breast Cancer
Leptomeningeal carcinomatosis is a serious complication of advanced cancer. Various clinical manifestations may present, such as headache, nausea, seizures, cranial neuropathies. In this article, we report the case of a 65-year-old woman with metastatic breast cancer who was admitted to hospital suffering from facial palsy, which was suspected to be caused by leptomeningeal tumor infiltration. ...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 2014
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2014-0199